Wegovy vs Zepbound
Wegovy (semaglutide) and Zepbound (tirzepatide) are the two most-prescribed GLP-1 weight loss injections in the US. Both are FDA-approved for chronic weight management, but they work slightly differently and produce different average results.
Written and fact-checked by ClearlyMeds Editorial Team. Published April 6, 2026. Last updated April 6, 2026.
Provider prices last verified April 6, 2026.
This page has not been medically reviewed by a licensed clinician. It is educational content, not medical advice.
| Category | Wegovy | Zepbound | Winner |
|---|---|---|---|
| Drug class | GLP-1 receptor agonist | GLP-1 + GIP receptor agonist | Zepbound |
| Average weight loss (68 weeks) | 15% of body weight | 18-21% of body weight | Zepbound |
| FDA approved for weight loss | Yes (2021) | Yes (2023) | Wegovy |
| Insurance coverage | Wider coverage | Growing but narrower | Wegovy |
| Common side effects | Nausea, diarrhea, constipation | Nausea, diarrhea, injection site reactions | Wegovy |
| Track record | Longer real-world data | Newer but strong trials | Wegovy |
| Starting dose | 0.25 mg weekly | 2.5 mg weekly | Tie |
| Best for | Patients with broad insurance coverage | Patients wanting maximum weight loss | Tie |
Final verdict
Zepbound shows slightly stronger average weight loss in clinical trials, but Wegovy has a longer track record and wider insurance coverage. The best choice depends on your insurance formulary, tolerance for side effects, and what your doctor recommends.
Frequently asked questions
Which wins for Drug class: Wegovy or Zepbound?
Zepbound wins for Drug class.
Which wins for Average weight loss (68 weeks): Wegovy or Zepbound?
Zepbound wins for Average weight loss (68 weeks).
Which wins for FDA approved for weight loss: Wegovy or Zepbound?
Wegovy wins for FDA approved for weight loss.
Which wins for Insurance coverage: Wegovy or Zepbound?
Wegovy wins for Insurance coverage.
Which wins for Common side effects: Wegovy or Zepbound?
Wegovy wins for Common side effects.
Which wins for Track record: Wegovy or Zepbound?
Wegovy wins for Track record.
Which wins for Starting dose: Wegovy or Zepbound?
Wegovy and Zepbound are effectively tied on Starting dose.
Which wins for Best for: Wegovy or Zepbound?
Wegovy and Zepbound are effectively tied on Best for.